Microscopic view of a Clostridium difficile bacterium surrounded by tangled structures.

What is Clostridium difficile and Why its New Guidelines Affect Hand Hygiene

C. diff, the common shorthand for the pathogenic bacterium Clostridioides difficile (formerly Clostridium difficile), is not a bug you want to pass around. Infection with C. difficile causes debilitating diarrhea and intestinal inflammation—leading to death in 15,000 patients in the U.S. each year. It is notoriously difficult to treat. Often after years of struggle with …

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